5th November — 17:00 UTC (check local time)

Prof. H. Uri Saragovi
Professor at the Jewish General Hospital, McGill University. Speaking from Montreal, Quebec, Canada.

"Validation of New Targets and Mechanisms in Neuroprotection"

p75 or proNGF antagonists delay progression of neuro-vascular-inflammatory disease. Trk agonists are neuroprotective, but truncated Trks can be pathological. TrkC.T1 is a novel target with a different ectodomain conformation and ligand-engagement. 

22nd October — 16:00 UTC (check local time)

Blaine Connor
PhD candidate in Rejji Kuruvilla's lab at the Department of Biology, John Hopkins University. Speaking from Baltimore, MD, USA.

"Transcytosis of TrkA Receptors in Sympathetic Neuron Development"

Neuron development, function, and viability rely on correct targeting of membrane proteins to functional sites in axons after biosynthesis in cell bodies. A non-canonical pathway for TrkA receptors mediates growth and survival in sympathetic neurons.

8th October — 12:00 UTC (check local time)

Elizabeth Coulson
Head of the Neurotrophins in Alzheimer's Lab. Professor of Neuroscience, School of Biomedical Science and Queensland Brain Institute, The University of Queensland. Speaking from Brisbane, Australia.

"p75 cleavage-mediated neuronal death due to sleep apnea: risk for AD"

Intermittent hypoxia but not sleep deprivation in mouse models results in the death of cholinergic basal forebrain neurons, a risk factor for Alzheimer's. The neuronal death is mediated by p75 cleavage, which has been demonstrated by a novel cleavage-resistant knockin mouse.

24th September — 14:00 UTC (check local time)

Svitlana Bach
Postdoctoral Fellow in Keri Martinowich's lab at the Lieber Institute for Brain Development, John Hopkins University. Speaking from Baltimore, MD, USA.

"Distinct roles of Bdnf I and Bdnf IV expression in the brain"

Brain-derived neurotrophic factor (Bdnf) is transcribed from several promoters producing different transcripts. Using CRISPR activation, we selectively upregulate activity-dependent Bdnf I and IV to study their distinct roles in neurons.

10th September — 16:00 UTC (check local time)

Subhashini Joshi
Graduate student in Prof. Wilma Friedman's lab at Rutgers University. Speaking from Newark, NJ, USA.

"p75NTR regulates oligodendrocyte development in the postnatal rat SVZ"

In this study we show that the absence of p75NTR reduces the proliferative capacity of subventricular zone progenitor cells and promotes their differentiation along the oligodendrocyte lineage in postnatal rats.

27th August — 16:00 UTC (check local time)

Francisca Bronfman
Full Professor at the Institute of Biomedical Sciences, Faculty of Medicine, Universidad Andrés Bello. Speaking from Santiago, Chile.

"Regulation of neuronal plasticity by BDNF signaling endosomes"

I will address the cellular mechanism by which BDNF/TrkB in axons controls nuclear CREB phosphorylation and cell body PI3K-mTOR activity to induced dendritic arborization.

13th August — 16:00 UTC (check local time)

Zhenyi Hong
Post doctoral fellow in the lab of Prof. Lino Tessarollo at the National Institutes of Health. Speaking from Frederick, MD, USA.

"Novel metabolic role for BDNF in pancreatic β-cell insulin secretion"

TrkB.T1 is expressed in pancreatic β-cells where it regulates insulin release. The finding that BDNF is secreted by differentiated human muscle cells and induces insulin secretion in islets via TrkB.T1 identifies a new regulatory function of BDNF on metabolism that is independent of CNS activity.

30th July — 15:00 UTC (check local time)

Eitan Zahavi
Post doctoral fellow in the lab of Prof. Casper Hoogenraad at Utrecht University. Speaking from Utrecht, The Netherlands.

"Combined Kinesin-1 and Kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers"

We uncovered a novel pathway for the direct delivery of the TrkB receptor from the secretory pathway into the distal axon. The receptor is transported in Rab6 carriers by the combined activity of Kinesin-1 and Kinesin-3 motors which play distinct role in the formation and entry into the axon. 

16th July — 20:00 UTC (check local time)

Paula Díaz
PhD Student at the Physiology Department, Faculty of Biological Sciences, Pontificia Universidad Católica de Chile. Speaking from Santiago, Chile.

"Lack of skin-secreted neurotrophic factors results in a small fiber neuropathy"

Small-fiber neuropathy (SFN) is the result of dysfunction of the small unmyelinated fibers that innervate the skin. SFN is one of the most frequent and troublesome complications of Recessive Dystrophic Epidermolysis Bullosa (RDEB). Intraepidermal fibers degenerate in the skin of RDEB and fail to regenerate. In this study we aim to investigate the mechanisms behind this failure by focusing on neurotrophins secreted by skin cells. Once the factor is identified, we will intend to use it as a therapeutic option for SFN in RDEB. 

2nd July — 16:00 UTC (check local time)

Oscar Lazo
Research Fellow at the UCL Queen Square Institute of Neurology and UK Dementia Research Institute. Speaking from London, United Kingdom.

"Rab10 as a novel regulator of the sorting of TrkB receptors to retrograde axonal transport"

Neurotrophic signalling from the axon terminal is propagated retrogradely by organelles called signalling endosomes. At arrival to the soma, these organelles have diverse destinations and regulate several neuronal functions; however, the molecular signatures that control their sorting, transport and specific targeting is only partially understood. We have found that the monomeric GTPase Rab10 regulates the sorting of TrkB internalised receptors to retrograde axonal transport and hence propagation of neurotrophic signalling. Interestingly, Rab10 organelles are mobilised towards the periphery upon stimulation with BDNF, providing a mechanism to calibrate retrograde signalling to variations in neurotrophins concentrations, with high therapeutic potential for neurodegenerative diseases. 

18th June — 08:00 UTC (check local time)

Carlos Ibañez
Professor, joint appointment at Karolinska Institute, Stockholm, Sweden, and National University of Singapore. Speaking from Singapore.

"Genetic dissection of death receptor p75NTR signaling in a mouse model of Alzheimer’s Disease"

No abstract available. 

4th June — 14:00 UTC (check local time)

Plinio Casarotto
Postdoctoral Researcher at the Unversity of Helsinki. Speaking from Helsinki, Finland.

"TrkB cholesterol-interacting motif as a target for drug-induced plasticity"
 

We described a cholesterol-interacting motif at the transmembrane domain of TRKB, a BDNF receptor promoting neuronal plasticity and antidepressant responses, where antidepressants can interact with. Mutation of this motif impaired cellular and behavioral responses to antidepressants in vitro and in vivo. We suggest that interaction with TRKB and the allosteric facilitation of BDNF signaling is the common mechanism for antidepressant action, which proposes a framework for how molecular effects of antidepressants are translated into clinical mood recovery. 

21st May — 20:00 UTC (check local time)

Sofía Lizarraga
Assistant Professor in Biological Sciences at University of South Carolina. Speaking from Columbia SC, USA.

"Epigenetic regulation of neurotrophin signaling in autism spectrum disorders"

The histone methyl transferase-ASH1L is a major genetic risk factor for autism. We show that ASH1L regulates neuronal morphogenesis by counteracting the catalytic activity of Polycomb-PRC2 and modulating the BDNF-TrkB signaling pathway in stem cell-derived human neurons.  

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