2nd July — 16:00 UTC (check local time)
Research Fellow at the UCL Queen Square Institute of Neurology and UK Dementia Research Institute. Speaking from London, United Kingdom.
"Rab10 as a novel regulator of the sorting of TrkB receptors to retrograde axonal transport"
Neurotrophic signalling from the axon terminal is propagated retrogradely by organelles called signalling endosomes. At arrival to the soma, these organelles have diverse destinations and regulate several neuronal functions; however, the molecular signatures that control their sorting, transport and specific targeting is only partially understood. We have found that the monomeric GTPase Rab10 regulates the sorting of TrkB internalised receptors to retrograde axonal transport and hence propagation of neurotrophic signalling. Interestingly, Rab10 organelles are mobilised towards the periphery upon stimulation with BDNF, providing a mechanism to calibrate retrograde signalling to variations in neurotrophins concentrations, with high therapeutic potential for neurodegenerative diseases.