24th September — 14:00 UTC (check local time)

Svitlana Bach
Postdoctoral Fellow in Keri Martinowich's lab at the Lieber Institute for Brain Development, John Hopkins University. Speaking from Baltimore, MD, USA.

"Distinct roles of Bdnf I and Bdnf IV expression in the brain"

Brain-derived neurotrophic factor (Bdnf) is transcribed from several promoters producing different transcripts. Using CRISPR activation, we selectively upregulate activity-dependent Bdnf I and IV to study their distinct roles in neurons.

*|END:WEB_VIDEO|*

8th October — 12:00 UTC (check local time)

Elizabeth Coulson
Head of the Neurotrophins in Alzheimer's Lab. Professor of Neuroscience, School of Biomedical Science and Queensland Brain Institute, The University of Queensland. Speaking from Brisbane, Australia.

"p75 cleavage-mediated neuronal death due to sleep apnea: risk for AD"

Intermittent hypoxia but not sleep deprivation in mouse models results in the death of cholinergic basal forebrain neurons, a risk factor for Alzheimer's. The neuronal death is mediated by p75 cleavage, which has been demonstrated by a novel cleavage-resistant knockin mouse.

22nd October — 16:00 UTC (check local time)

Blaine Connor
PhD candidate in Rejji Kuruvilla's lab at the Department of Biology, John Hopkins University. Speaking from Baltimore, MD, USA.

"Transcytosis of TrkA Receptors in Sympathetic Neuron Development"

Neuron development, function, and viability rely on correct targeting of membrane proteins to functional sites in axons after biosynthesis in cell bodies. A non-canonical pathway for TrkA receptors mediates growth and survival in sympathetic neurons.

5th November — 17:00 UTC (check local time)

Prof. H. Uri Saragovi
Professor at the Jewish General Hospital, McGill University. Speaking from Montreal, Quebec, Canada.

"Validation of New Targets and Mechanisms in Neuroprotection"

p75 or proNGF antagonists delay progression of neuro-vascular-inflammatory disease. Trk agonists are neuroprotective, but truncated Trks can be pathological. TrkC.T1 is a novel target with a different ectodomain conformation and ligand-engagement. 

The NGF Webinar Series 2020 is an initiative of a group of early-career scientists to keep our field connected during this challenging times and beyond. You can contact us by using the registration form or our social networks.