8th April — 15:00 UTC (TBC) (check local time)
Research Director of the Institute of Chemical Biology, National Hellenic Research Foundation. Speaking from Athens, Greece.
New steroid-based selective neurotrophin mimetics.
Neurosteroid DHEA, acts as neurotrophic factor in the brain and prevents neuronal apoptosis by interacting with the TrkA and p75NTR receptors. Series of 17-spiro DHEA analogues were synthesized resulting in selective TrkA or TrkB agonists with neuroprotective/neuroregenerative activity. .