11th November — 15:00 UTC (check local time) 

Viviana Pérez
Postdoctoral fellow at the labs of Francisca Bronfman (Universidad Andrés Bello) and Juan Pablo Henríquez (Universidad de Concepción). Speaking from Concepción, Chile.

p75 and TrkB/CREB: key organizers of the mature neuromuscular junction.

Our findings show that: (a) the absence of the p75 receptor impairs the morphology and function of the mature NMJ and alters skeletal muscle organization, and (b) CREB activation by a BDNF/TrkB pathway controls the organization of mature NMJs.

9th December — 16:00 UTC (check local time) 

James Sleigh
Senior research fellow and group leader at the Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology. Speaking from London, United Kingdom.

Restoring axonal transport as a therapeutic strategy in CMT.

We identified early in vivo deficits in axonal transport of signalling endosomes in mice modelling Charcot-Marie-Tooth disease (CMT). This impairment is rescued by intramuscular delivery of BDNF, indicating that restoring transport by targeting muscle may be a viable therapeutic strategy for CMT.

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